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CASE REPORT
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Increased expression of BDNF and inflammatory biomarkers in type 2 diabetes-related claustrophobia: A case report


1 Sharjah Institute for Medical Research, University of Sharjah, Sharjah, UAE
2 Basic Medical Science Department, College of Medicine, University of Sharjah, Sharjah, UAE
3 Diabetes and Endocrinology Department, University Hospital Sharjah, Sharjah, UAE; Clinical Sciences Department, College of Medicine, University of Sharjah, Sharjah, UAE

Correspondence Address:
Bashair M Mussa,
Basic Medical Science Department, College of Medicine, University of Sharjah, Sharjah, P. O. Box 27272
UAE
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/abhs.abhs_23_22

Type 2 diabetes mellitus (T2DM) is widely known to cause damage to several organ systems resulting in complications such as neuropathy, nephropathy, and retinopathy. A characteristic feature of T2DM is hyperglycemia, which can adversely affect the brain and cause psychological disorders such as anxiety and depression. Although several studies have reported a strong association between T2DM and psychological disorders, it is surprising that the latter is not well investigated. Therefore, the main objectives of this case report are to (i) emphasize the association between psychological disorders and T2DM and (ii) investigate the expression of brain-derived neurotrophic factor (BDNF) and inflammatory markers in a case of T2DM-related claustrophobia. By investigating the blood and saliva samples of a 40-year-old male suffering from T2DM and claustrophobia, we report a highly significant increase in BDNF expression and inflammatory biomarkers interleukin-6 and monocyte chemoattractant protein-1 along with a concomitant decrease in interleukin-8 and transforming growth factor-beta. Based on these observations, we propose the presence of a correlation between increased BDNF expression, inflammation, and diabetes-related claustrophobia. Outcomes from this report further highlight the significance of considering T2DM-related psychological disorders as an essential diagnostic measure.


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    -  Srivastava A
    -  Mussa BM
    -  Abusnana S
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